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Background of Clinical Indications
Clinically, it is mainly used to observe the indicators of hepatic cirrhosis. Its concentration is related to the degree of hepatic fibrosis. The degree of hepatic cirrhosis can be inferred from the serum type IV collagen concentration. For patients with chronic hepatitis and hepatic cirrhosis, serum type IV collagen significantly increased, and the degree of increase is accordingly for patients with hepatic cirrhosis, chronic active hepatitis, chronic persistent hepatitis, and acute viral hepatitis. When the tissues and organs rich in vascular basement membrane have pathological changes, the abnormal and obvious level of type IV collagen and its degradation fragments can also appear, such as hyperthyroidism, scleroderma, middle and advanced diabetes, etc.