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Background of Clinical Indications
Increased 5'-Nucleotidase activity is common in patients with primary and metastatic liver disorder, pancreatic disorder, biliary obstruction, cholangitis, acute and chronic hepatitis, hepatic cirrhosis, and drug-induced liver injury. Its activity can be increased by 2 to 6 times, and it is positively correlated with the severity of the disease, which can help determine the alkaline phosphatase to occur in hepatobiliary disorders or bone marrow disorders. ALP is increased in hepatobiliary disorders and diseases of skeletal system. For 5-NT, except for increase in hepatobiliary disorders, it is generally not increased in diseases of skeletal system. It is helpful for the differential diagnosis of hepatocellular jaundice and obstructive jaundice. 5-NT in the latter is significantly higher than that in the former.