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Background of Clinical Indications
It is used for the auxiliary diagnosis of coronary heart disease and cerebrovascular disease. ApoA1 is an anti-atherosclerosis indicator. Its decrease can be seen in patients with nephrotic syndrome, active hepatitis, liver parenchymal damage, and diabetes, etc. ApoA1 (together with ApoA2) accounts for 80% to 90% of HDL protein. Therefore, ApoA1 in serum can represent the level of HDL, which is obviously positively correlated with HDL-C. ApoA1 is low in patients with coronary heart disease and cerebrovascular disease, and ApoA1 is extremely low in serum of patients with ApoA1 deficiency, clustered hypo-α lipoproteinemia, and fisheye disease. HDL-C is often low in patients with cluster hypertriglyceridemia, but ApoA1 is not necessarily low, which does not increase the risk of coronary heart disease.